Everything about Lantibiotics totally explained
Lantibiotics are a class of
peptide antibiotics that contain polycyclic
thioether amino acids as well as the
unsaturated amino acids
dehydroalanine and
2-aminoisobutyric acid. These characteristic cyclic thioether amino acids are composed of either
lanthionine or
methyllanthionine. Lantibiotics are produced by a large number of
Gram positive bacteria such as
Streptococcus and
Streptomyces to attack other gram positive bacteria and as such they're considered a member of the
bacteriocins.
Lantibiotics are well studied because of the commercial use of these bacteria in the food industry for making dairy products such as
cheese. Bacteriocins are classified according to their extent of
posttranslational modification. The
lantibiotics are a class of more extensively modified bacteriocins, also called Class I. Bacteriocins for which
disulfide bonds are the only modification to the peptide are Class II bacteriocins. Most bacteriocins are biologically active single-chain peptides. Some are only active as partners with a second peptide (see Class IIb, below).
Nisin and
epidermin are members of a family of lantibiotics that bind to a
cell wall precursor lipid component of target bacteria and disrupt cell wall production. The duramycin family of
lantibiotics binds
phosphoethanolamine in the
membranes of its target cells and seem to disrupt several physiological functions.
History
The name Lantibiotics was introduced in 1988 as an abbreviation for "Lanthionine-containing peptide
antibiotics". The first structures of these
antimicrobial agents were produced by pioneering work by Gross and Morell in the late sixties and early seventies, thus marking the formal introduction of Lantibiotics. Since then Lantibiotics such as
Nisin have been used auspiciously for food preservation and have yet to encounter significant bacterial resistance. These attributes of lantibiotics have led to more detailed research into their structures and
biosynthetic pathways.
Classification
Biosynthesis
The biosynthesis is interesting
. They are synthesised with a leader polypeptide sequence which is only removed during the transport of the molecule out of the synthesising cell.
Mechanism of action
Lantibiotics show substantial specificity for some components (eg lipid II) of bacterial cell membranes especially of Gram positive bacteria. Type A kill rapidly by pore formation, type B inhibit peptidoglycan biosynthesis. See Brotz and Sahl. JAC (2000) 46, 1-6 for discussion of mechanism of action. They are active in very low concentrations.
Application
Lantibiotics are produced by Gram-positive bacteria and show strong antimicrobial action towards a wide range of other Gram-positive bacteria. As such they've become attractive candidates for use in food preservation (by inhibiting pathogens that cause food spoilage) and the pharmaceutical industry (to prevent or fight infections in humans or animals). See C. van Kraaij et al, Nat. Prod. Rep. (1999), 16, 583 - 584 for more detailed disccusion of the pharmaceutical application of lantibiotics.
Further Information
Get more info on 'Lantibiotics'.
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